PRO-VET® Ultimate

Indication

PRO-VET® Ultimate complete and balanced dry diet food for adult dogs of all breeds with food allergy, food intolerance (hypersensitivity disorders) or atopy (allergic dermatitis); suitable for dogs with heart failure (cardiomyopathy).
The combined characteristics of PRO-VET® Ultimate makes this ration useful in the treatment of various canine disorders. Food hypersensitivity and atopy often co-exist in dogs and it is difficult to distinguish definitively between the two conditions. PRO-VET® Ultimate makes it possible to treat both patients with food hypersensitivity and those with atopy.
Chopping proteins into smaller peptide fragments decreases their antigenicity. This principle extends to dogs with food hypersensitivity. Dogs with hypersensitivity towards soy protein developed pruritis upon ingesting the intact protein, but did not do so with hydrolysed soy protein.
PRO-VET® Ultimate is hypoallergenic diet which contains hydrolyzed proteins which have been used as an elimination diet. So far elimination diets with hydrolyzed and parent proteins have not been compared directly, but based on data for elimination diets with intact and hydrolyzed proteins it could be suggested that hypoallergenic diets as PRO-VET® Ultimate with hydrolyzed proteins is more effective than those with intact proteins in the management of food hypersensitivity.

Atopy and food hypersensitivity often go hand in hand and have similar clinical signs, but skin disorders caused by inhaled allergens will not react to hypoallergenic protein sources. The treatment of atopic dermatitis involves the suppression of chronic inflammatory reactions in the skin. PRO-VET® Ultimate contents eicosanoids formed from di-homo-gamma linolenic acid and from eicosapentaenoic acid (EPA) so that PRO-VET® Ultimate has an anti-inflammatory properties.

Double blind, placebo-controlled experiments by dogs with atopic dermatitis have shown that supplements of both borage oil, which is rich in gamma-linolenic acid (GLA) and fish oil, which is rich in EPA, lower the severity of pruritis, erythema and self-trauma. Good results have been obtained with a diet rich in both fish oil and borage oil. PRO-VET® Ultimate contains about 0.5% borage oil and 5% fish oil. The efficiancy of PRO-VET® Ultimate was tested in four clinics using a double blind, placebo-controlled design. After 10 weeks on the diet, the scores for pruritis and erythema had decreased to about half, while the control treatment had no influence. According to the owners the diet had improved skin condition by 60% of the dogs. Clearly, a substantial number of the patients with atopic dermatitis will improve after feeding PRO-VET® Ultimate enriched with suitable amounts of fish oil and borage oil. However, there will be great differences in individual responsiveness.

By dogs with idiopathic chronic colitis or inflammatory bowel disease, the feeding of a hypoallergenic diet as PRO-VET® Ultimate based on a hydrolyzed protein source caused a significant decrease in clinical signs. Ingestion of fish oil may be expected to further improve the clinical condition through its anti-inflammatory activity. By humans with ulcerative colitis such a positive effect has been demonstrated.

In patients with heart failure the development of anorexia and cachexia probably is mediated by increased levels TNF and IL-1 in the blood. A placebo-controlled study in dogs with heart failure showed that dietary fish oil lowered the plasma concentrations of TNF and IL-1 and counteracted cachexia. The amount of fish oil administered was equivalent to 1.3% in a dry food.

Dogs are able to synthesize taurine, but a deficiency may develop through a metabolic disorder in combination with low intake. Dogs are also able to synthesize carnitine, but analogous to taurine deficiency, a carnitine deficiency can also develop. Dogs with cardiomyopathy associated with a low carnitine concentration in heart muscle may show improvement after carnitine supplementation. In a randomised, placebo-controlled, double-blind study it was shown that heart function and survival of dogs with cardiomyopathy and low plasma levels of taurine had improved after supplementation of a combination of taurine and carnitine. Using PRO-VET® Ultimate all patients could successfully be weaned off medication. To treat cardiomyopathy, the appropriate doses of taurine and L-carnitine in a dry diet appear to be 0.15 and 0.075%, respectively present in PRO-VET® Ultimate.

Efficacy

Composition

Rice, Hydrolysed Fish Protein, Potato Protein, Animal Fat (Poultry, Beef), Premium Pure Norwegian Salmon Oil, Minerals (Monocalcium Phosphate, Calcium Carbonate, Potassium Chloride), Dried Beet Pulp, Hydrolysed Soya Protein Isolate, Purified Vegetable Fibre (Cellulose), Hydrolysed Chicken Liver, Mannanoligosaccharides (MOS), Borage Seed Oil (Borago Officinalis), Lineseed Oil, Inulin (source of Fructooligosaccharides (FOS)).

With oxidation reducing substance strong tocopherol-rich extract (Vitamin E) of natural origin (from Vegetable Oils). PRO-VET® products meet the requirements as stated by AAFCO, NRC and/or FEDIAF. Produced and packed in Holland, production takes place under certification of: NEN ISO 9001 / GMP+.

Analyses

Energy Value 4062 Kcal/kg [17.0 MJ.kg]

Vitamins:
Vitamin A (Retinyl Acetate)
Vitamin D3 (Cholecalciferol)
Vitamin E (all-rac-Alpha-Tocopherol Acetate)
Vitamin K3 (Menadione Nicotinamide Bisulfite)

Trace Elements/kg:
Iron (Fe) (Iron-(II)-Sulphate Monohydrate) 51 mg
Manganese (Mn) (Manganese-(II)-Oxide) 19 mg
Copper (Cu) (Cupric-(II)-Sulphate Pentahydrate) 9 mg
Zinc (Zn) (Zinc Sulphate Monohydrate) 90 mg
Iodine (I) (Potassium Iodide) 1 mg
Selenium (Se) (Sodium Selenite) 0.20 mg

Other Nutritional Additives/kg:
L-Lysine 750 mg
L-Carnitine 750 mg
Taurine 1.500 mg

Directions for use: The kibbles are ready to be eaten. Make sure that you always provide plenty of fresh and available drinking water for your dog. Regularly clean food and water bowls. Store in a cool dry place, away from direct sunlight. Feeding guide: Because each dog has different requirements, the recommended daily quantities on the packaging should only be used as a guide. This is a guide only as an individual dog’s requirements will vary depending on various factors including breed, activity level, metabolism, age and environment. Feeding quantities should be adjusted to suit your individual dog’s requirements. The amount of feed the best to divide into two meals per day.

In the case of skin disorders, the recommended duration of feeding this diet is 3 to 8 weeks; if the signs disappear this feed can be used indefinitely. In the case of heart failure, the initial recommeded duration of feeding this diet is up to 6 months.

Feeding Guide

Package

2.5kg   EAN 8717496486301
7.5kg   EAN 8717496489951

Storage

While dry food will not spoil as rapidly as other types of food, it does not last indefinitely. Always make sure that you use such foods before the expiration date. Keep the food dry and store it inside the bag it came in; we design the bags to resist moisture and airflow. The best way to store a large bag of dog or cat food is to place the original bag inside a clean plastic pail or container with a secure lid. Do not store dry food in humid rooms, as damp conditions will accelerate spoiling. Always roll the top of the bag down tightly and cinch it closed with a clip. The Center for Disease Control and Prevention recommends that pet owners keep dry foods and treats in locations that do not exceed 23 °C (degrees Calsius) or 74 °F (degrees Fahrenheit).  

A healthy dog is a happy dog.